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It is sometimes difficult to reach a celiac disease diagnosis. Celiac disease does not always present in a clear manner, as there are many clinical forms of presentation.
The ingestion of food containing gluten, such as pasta, bread, biscuits or even traces of flour from prohibited cereals, triggers an abnormal immune response in the intestine of a genetically predisposed subject, followed by a chronic inflammation and the disappearance of the intestinal villi.
The onset of significant diseases, which are sometimes irreversible, can occur in the event of late celiac disease diagnosis, such as osteoporosis, infertility, habitual abortion, short stature in children, diabetes mellitus, autoimmune thyroiditis, alopecia, epilepsy with cerebral calcifications and the much feared intestinal lymphoma.
The symptoms in the typical form are diarrhea and impaired growth (after weaning) and the atypical form presents later with prevalently extraintestinal symptoms (for example anemia), the peculiarity of the silent form is the absence of striking symptoms and the potential (or latent) form may be diagnosed with positive serum tests but with a normal intestinal biopsy.
A celiac disease diagnosis is made through serological tests: the AGA (IgG- and IgA-antigliadin antibodies), and the EMA (IgA-antiendomysium antibodies). A new antibody assay, the IgA anti-transglutaminase antibody test, was devised recently.
However, for a definitive celiac disease diagnosis, it is essential to obtain a tissue sample from a biopsy of the small intestine as histological testing of this sample will determine whether the intestinal villi have atrophied.
Eurospital has devised a brand new rapid test for making a celiac disease diagnosis in a safe, practical and non-invasive manner. This test may be performed at home on both adults and children. Just one drop of blood is sufficient and it is not necessary to go to hospital to provide a sample. The sensitivity of this test is 96.3%, and this has also been proven in a study conducted by the “Burlo Garofalo” Pediatric Institute, Trieste. The kit may be purchased in pharmacies without the need for a doctor’s prescription and may be performed easily at home. However, should the result of the test be positive, it is advisable to see a physician straight away so that subsequent tests may be carried out in order to provide a definitive and correct celiac disease diagnosis. continue >>